KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
12.12
Human Site:
Y409
Identified Species:
26.67
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
Y409
S
A
D
L
N
R
N
Y
S
K
S
T
E
L
P
Chimpanzee
Pan troglodytes
XP_519168
792
88529
Y421
S
A
D
L
N
R
N
Y
S
K
S
T
E
L
P
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
P368
P
V
P
P
I
L
T
P
S
P
P
S
A
F
P
Dog
Lupus familis
XP_540396
757
85032
Y384
S
T
D
L
N
R
N
Y
N
K
S
A
E
L
P
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
Y408
P
A
D
L
N
R
S
Y
D
K
S
A
D
Q
W
Rat
Rattus norvegicus
NP_476456
766
85965
P401
M
A
S
P
E
Q
P
P
T
D
L
N
R
N
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
L381
S
E
Q
H
A
P
D
L
N
E
N
Y
S
K
S
Chicken
Gallus gallus
XP_415970
1211
131521
N830
H
S
T
D
L
N
E
N
Y
N
K
T
T
E
L
Frog
Xenopus laevis
NP_001084841
660
74123
Q295
R
A
I
A
Q
L
F
Q
K
Q
L
E
V
Y
E
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
S205
D
V
P
S
S
F
D
S
I
L
D
M
I
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
K442
K
A
T
L
S
A
F
K
D
I
E
F
D
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
100
13.3
80
N.A.
53.3
6.6
N.A.
6.6
6.6
6.6
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
20
86.6
N.A.
66.6
20
N.A.
33.3
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
55
0
10
10
10
0
0
0
0
0
19
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
37
10
0
0
19
0
19
10
10
0
19
0
0
% D
% Glu:
0
10
0
0
10
0
10
0
0
10
10
10
28
19
10
% E
% Phe:
0
0
0
0
0
10
19
0
0
0
0
10
0
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% G
% His:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
10
0
0
0
10
10
0
0
10
0
0
% I
% Lys:
10
0
0
0
0
0
0
10
10
37
10
0
0
10
0
% K
% Leu:
0
0
0
46
10
19
0
10
0
10
19
0
0
28
19
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
37
10
28
10
19
10
10
10
0
10
0
% N
% Pro:
19
0
19
19
0
10
10
19
0
10
10
0
0
0
37
% P
% Gln:
0
0
10
0
10
10
0
10
0
10
0
0
0
10
0
% Q
% Arg:
10
0
0
0
0
37
0
0
0
0
0
0
10
0
0
% R
% Ser:
37
10
10
10
19
0
10
10
28
0
37
10
10
0
10
% S
% Thr:
0
10
19
0
0
0
10
0
10
0
0
28
10
0
0
% T
% Val:
0
19
0
0
0
0
0
0
0
0
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
0
0
0
0
0
37
10
0
0
10
0
10
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _